Systematic review of outcome measures in trials of pediatric anaphylaxis treatment
نویسندگان
چکیده
BACKGROUND Considerable heterogeneity has been observed in the selection and reporting of disease-specific pediatric outcome measures in randomized controlled trials (RCTs). This makes interpretation of results and comparison across trials challenging. Outcome measures in pediatric anaphylaxis trials have never previously been systematically assessed. This systematic review (SR) identified and assessed outcome measures used in RCTs of anaphylaxis treatment in children. As a secondary objective, this SR assessed the evidence for current treatment modalities for anaphylaxis in the pediatric population. METHODS We searched MEDLINE, EMBASE, The Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL from 2001 until December 2012. We also searched websites listing ongoing trials. We included randomized and controlled trials of anaphylaxis treatment in patients 0-18 years of age. Two authors independently assessed articles for inclusion. RESULTS No published studies fulfilled the inclusion criteria. CONCLUSIONS There is an alarming absence of RCTs evaluating the treatments for anaphylaxis in children. High quality studies are needed and are possible to design, despite the severe and acute nature of this condition. Consensus about the selection and validation of appropriate outcome measures will enhance the quality of research and improve the care of children with anaphylaxis. TRIAL REGISTRATION CRD42012002685.
منابع مشابه
Probiotics for the Treatment of Asthma: A Systematic Review and Meta-Analysis of Randomized Trials
Background: Asthma is a growing problem worldwide and the limitations of the current therapy for allergic asthma highlight the need for novel therapeutics. We conducted a systematic review and meta-analysis to find out the role of probiotics in the treatment of Asthma. <stron...
متن کاملAntiviral agents for preventing cytomegalovirus infection in pediatric renal transplant recipients: A systematic review
Background and Objective: Cytomegalovirus (CMV) infections are associated with severe morbidity and mortality in patients, especially pediatric renal transplantation patients. The use of immunosuppressive agents places these patients at the risk of viral infections. As cytomegalovirus infection influences the graft outcome, adopting useful strategies for limiting this virus after transplantatio...
متن کاملCurrent Indications of Bone Marrow Transplantation (BMT) in Pediatric Malignant Conditions a Review
Hematopoietic stem cell transplantation (HSCT) has been practiced for more than 30 years. Hematological malignanciesare the main indications for this treatment. However, its indications in adults are different from children.Advances in chemotherapy and target therapy have improved treatment outcome of some of the very high riskcancers, and changed indications of HSCT in children. Multi-center c...
متن کاملComparison of Custom-made Versus Prefabricated Thumb Splinting for Carpometacarpal Arthrosis: A Systematic Review and Meta-analysis
Background: The goal of this study was to compare the two types of orthoses, prefabricated soft splints versus shortthermoplastic custom-made splints, that are the most commonly used for the management of first carpometacarpal(CMC) osteoarthritis (OA).Methods: We conducted a meta-analysis and systematic review in the literature based on the Preferred ReportingItems for Systematic Reviews and Me...
متن کاملSystematic review of outcome measures in pediatric eosinophilic esophagitis treatment trials
BACKGROUND Heterogeneity has been noted in the selection and reporting of disease-specific, pediatric outcomes in randomized controlled trials (RCTs). The consequence is invalid results or difficulty comparing results across trials. The primary objective of this systematic review was to assess primary outcome and outcome measure selection and reporting, in pediatric eosinophilic esophagitis (Eo...
متن کامل